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Chartres stained glass of occupations of the months:
This portion of an early 13th century stained glass panel in Chartres Cathedral shows the occupations of the months for September (harvesting grapes), October (barreling wine), November (killing a hog), and December (feasting). November is actually mislabeled as December, even though the image correctly labeled December sits directly above it. The matching zodiac symbols are also shown in the panel, but they are not visible in this picture -- they are just off to the left.
The image of Christ enthroned appears at the very top of the calendar (which is read from bottom to top). He sits between the Greek letters alpha and omega, showing Christ's dominion over time in its eternal sense.
In many ways, we don't think much about time in modern society. Time is all around us. We wear wristwatches. We have clocks on our cell phones, on our desks, in the corner of the computer screen. Even the home microwave shows the time. Our walls are littered with calendars. We use monthly planners, yearly planners, daily planners. We take it for granted that we know what time and day it is.
Such was not the case in the Middle Ages.
Before the end of the thirteenth century, the mechanical clock did not exist in Europe. Sundials, water clocks (which might freeze in the winter), or sand hourglasses were used to approximate the passage of the hours. All of these had serious drawbacks, but detailed timekeeping was not really necessary. Monastic timekeeping divided the day into "hours" spaced about 3 hours apart: matins (midnight), lauds (dawn), prime, tierce, sext, nones, vespers (evening), and compline (bedtime). This helped regulate the day by setting these 8 times for prayer and chants. The day was thus much more loosely regulated than our day which we measure by the minute on our digital clocks.
For most people, the year was also generally not measured by the passing of days, but rather by church festivals, agricultural seasons, and changes in the sky. Yet calendars as a source of information were always important to churchmen who needed to know the day in order to know which saint should be venerated. Manuscript calendars list every day of the month by the Roman dating system, which involved the ides and nones of the month rather than using the days of the week (Monday to Sunday) as we use them. This allowed one written calendar to be used every year rather than having to write out a new one each year like we do with our wall calendars. In these calendars, the occupations of the months and the signs of the zodiac often appear.
This does not mean however that people were unaware of time. As this exhibit will show, images of time played an important role in religious and secular spaces.
A Little Padding Helps, Too
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The researchers focused on the paraventricular nucleus (PVN) of the hypothalamus, located in the brain, an integration center between the central and peripheral nervous systems. The site is involved in numerous functions, including erectile function and sexual behavior, and is a primary site within the forebrain that has been implicated in penile erection. The investigators also examined central nitric oxide (NO within the PVN) which plays an important role in the neurotransmission of normal penile erection.
Besides treating the underlying causes and psychological consequences, the first line treatment of erectile dysfunction consists of a trial of PDE5 inhibitor drugs (the first of which was sildenafil or Viagra). In some cases, treatment can involve prostaglandin tablets in the urethra, intracavernous injections with a fine needle into the penis that cause swelling, a penile prosthesis, a penis pump or vascular reconstructive surgery.
"It has a long way to go, but the researchers have basically shown they can take cells from an organ, culture them, put them back in and have them be functional," McCullough said. "This is especially impressive because the penis is an organ that's a very sensitive hydraulic pump, so to speak. During an erection, blood has to flow into the organ. The organ then has to expand and then shut down the drainage so the blood doesn't flow back out. And all of these things are very interrelated."
Figure 5. Sildenafil down-regulates IL-4R expression on CD11b+ cells. CD4+, CD8+, CD11b+, or CD11c+ cells were magnetically purified from spleens of C26GM-bearing mice challenged 9 d earlier. CD4+ or CD8+ T cells were stimulated with ConA for 3 d, with or without 50 µg/ml sildenafil. (A) Purified cells were cultured separately for 2 d with or without sildenafil, harvested, and used to determine cGMP levels, as described in Materials and methods. (B) T cell proliferation was determined by [3H]thymidine incorporation. (C) CD11c+ cells were analyzed for B7.2 and MHC class II expression. (D) CD11b+ cells were analyzed for IL-4R expression by flow cytometry. The t test p-value is reported. Error bar values are shown. MFI, multiplicity of infection.
restoring nNOS protein within the PVN of diabetic rats with viral gene transfer could alleviate the blunted NMDA induced erectile responses.
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Treatments include psychotherapy, drug therapy, vacuum devices, and surgery.
Lipid profile: This blood test measures the level of lipids (fats), like cholesterol. High levels may indicate atherosclerosis (hardening of the arteries), which can affect blood circulation in the penis.
Erectile dysfunction or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. There are various underlying causes, such as diabetes, many of which are medically reversible.
About a month later, the tissue began to reconstitute itself, forming new blood vessel structures necessary for proper functioning, while nerves from the existing penile tissue integrated into the new tissue. In time, Atala said, the collagen structure was reabsorbed, and the cells built their own collagen structure.
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Many things can cause testosterone levels to be low, such as problems with the pituitary gland, which regulates the production of the sex hormone; thyroid abnormalities; liver problems; and abnormalities within the testes themselves. So if you're unable to get an adequate erection, it's possible that something is causing trouble with your body's testosterone production.
Figure 4. PDE5 inhibition increases intratumoral T cell infiltration and activation of tumor-specific CD8+ T cells. (A) BALB/c mice were challenged with CT26WT cells s.c. on day 0, and 20 mg/kg/d sildenafil was added to the drinking water where indicated. The mice were killed 15 d later, and the tumors were stained with hematoxylin-eosin. (B–D) BALB/c mice were challenged with C26GM on day 0. They were treated with sildenafil, received 20 x 106 C26GM vaccine-primed splenocytes from H2d pIL-2/GFP mice, or were given both treatments as indicated. (B) The tumors were surgically removed 9 d later, and the CD8+ T cell infiltrate was determined by flow cytometry. The percentage of CD8+ T cells was plotted against the tumor size at the time of tumor harvest. The software-provided tool (Sigma plot) was used to fit a three-parameter exponential decay curve (y = 36.13 + 92xe–5.93x). Pearson bivariate correlation, P = 0.0000002. Data are derived from three independent experiments, with each containing five mice per group. (C) Intratumoral single cell suspensions were labeled with anti-CD25 or -CD69 antibodies. Data are expressed as the percentage of positive cells gated on the CD8+ T cell population. (D) IL-2 production in the ACT groups is reported as the percentage of GFP+ CD8+ T cells. Data are derived from two independent experiments. The paired t test p-value is reported. (E) BALB/c mice were challenged with 0.5 x 106 C26GM cells on day 0. They were treated with sildenafil starting on day 0, the anti-CD8+ depleting antibody, or both. The one-way ANOVA p-values (PA) are indicated. Data are reported from one of two similar experiments. Error bar values are shown.
This test uses electromagnetic vibration to evaluate sensitivity and nerve function in the glans and shaft of the penis. A decreased perception of vibration may indicate nerve damage in the pelvic area, which can lead to impotence.
Men taking the protease inhibitor (for the treatment of HIV/AIDS) indinavir (Crixivan ) should not take more than 2.5 mg of vardenafil in a 24-hour period.
In the new study, published Jan. 1 in the journal Sleep, Gao and colleagues examined responses from 23,119 medical professionals, including physicians, veterinarians and pharmacists, who were asked questions about restless leg syndrome in 2002.
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